Compounds and method for coating surfaces in a hemocompatible manner

US8784862B2 · kind B2 · utility

Assignee

• Hemoteq AG · DE

Inventors

• Roland Horres · Stolberg, DE
• Marita Linssen · Oebisfelde, DE
• Michael Hoffmann · Walchwil, CH
• Erika Hoffmann · Eschweiler, DE
• Donate DiBiase · Aachen, DE
• Volker Faust · Aachen, DE

Key dates

• Filing date: Jun 30, 2010
• Grant date: Jul 22, 2014
• Expiry date: Mar 4, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.