Controlled release compositions for modulating free-radical induced damage and methods of use thereof

US8784870B2 · kind B2 · utility

Assignees

• OTONOMY, INC. · US
• The Regents of the University of California · US

Inventors

• Jay Lichter · Rancho Santa Fe, US
• Andrew M. Trammel · Olathe, US
• Fabrice Piu · San Diego, US
• Qiang Ye · San Diego, US
• Michael Christopher Scaife · Pittsburgh, US
• Benedikt Vollrath · San Diego, US
• Sergio G. Duron · San Diego, US
• Luis A. Dellamary · San Marcos, US
• Carl Lebel · Malibu, US
• Jeffrey P. Harris · Village of La Jolla, US

Key dates

• Filing date: Jul 21, 2009
• Grant date: Jul 22, 2014
• Expiry date: Sep 9, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).