Patent · US Active

Lipid therapy

US8785382B2 · kind B2 · utility

4Cited by

2References

18Claims

0Family size

Assignee

Abbott Cardiovascular Systems, Inc. · US

Inventors

Deborah Kilpatrick · Mountain View, US
Syed Faiyaz Ahmed Hossainy · Fremont, US
Irina Astafieva · Palo Alto, US
Florian N. Ludwig · Mountain View, US
Paul Consigny · San Jose, US
Jeffrey T. Ellis · Mountain View, US
Florencia Lim · Union City, US

Key dates

Filing date	Mar 30, 2007
Grant date	Jul 22, 2014
Priority date	—
Expiry date	Oct 19, 2028

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61M2202/0456
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo A1 comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo A1 and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCA1) transporter expression in macrophages and protect ABCA1 from thiol-mediated degradation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.