Compounds having anti-adhesive effects on cancer cells

US8785409B2 · kind B2 · utility

Assignees

• Geron Corporation · US
• The Board of Regents of the University of Texas System · US

Inventors

• Sergei Gryaznov · San Mateo, US
• Jerry Shay · Dallas, US
• Woodring Wright · Arlington, US

Key dates

• Filing date: Jan 30, 2008
• Grant date: Jul 22, 2014
• Expiry date: Jul 18, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the form O-(x-L)n, where O is an oligonucleoside having at least a plurality of N3′→P5′ thiophosphoramidate (NPS) internucleoside linkages, a conjugated lipid moiety L, and at least one G-rich sequence motif as described, are effective to morphologically alter and reduce adhesion of cancer cells.