Dosing regimen for a selective S1P1 receptor agonist
US8785484B2 · kind B2 · utility
17Cited by
9References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 12, 2009 |
| Grant date | Jul 22, 2014 |
| Priority date | — |
| Expiry date | Aug 12, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1P1 receptor agonist is administered at a dose which induces desensitization of the heart wherein said dose is below the target dose, and at a dosing frequency that sustains desensitization of the heart, until no further acute heart rate reduction occurs, followed by dose up-titration to the target dose of the selective S1P1 receptor agonist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.