Heteroaryl substituted indole compounds useful as MMP-13 inhibitors

US8785489B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Asitha Abeywardane · Danbury, US
• Bennett Farmer · Ridgefield, US
• Neil Alexander Farrow · Ridgefield, US
• Donghong Amy Gao · Hopewell Junction, US
• Alexander Heim-Riether · Ingelheim am Rhein, DE
• Lana Louise Smith Keenan · Poughquag, US
• Ingo Andreas Mugge · New Haven, US
• Steven John Taylor · Winchester, US
• Zhaoming Xiong · Brookfield, US
• Yang Yu · Jinan, CN
• Qiang Zhang · Dalian, CN

Key dates

• Filing date: Oct 13, 2009
• Grant date: Jul 22, 2014
• Expiry date: Mar 23, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.