L-ornithine phenyl acetate and methods of making thereof

US8785498B2 · kind B2 · utility

Assignee

• Ocera Therapeutics, Inc. · US

Inventors

• Keith Anderson · Nashville, US
• Jim Behling · Eagle River, US
• Christine Henderson Dougan · Glasgow, GB
• Stephen William Watt · Kilmarnock, GB
• Peter Manini · Giubiasco, CH
• Attilia Figini · Rancate, CH

Key dates

• Filing date: Jul 8, 2013
• Grant date: Jul 22, 2014
• Expiry date: Jul 8, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C229/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.