Anti-GCC antibody molecules and related compositions and methods

US8785600B2 · kind B2 · utility

Assignees

• Millennium Pharmaceuticals, Inc. · US
• AMGEN BRITISH COLUMBIA INC. · CA

Inventors

• Samuel S. Nam · Haverhill, US
• Edward A. Greenfield · Stoughton, US
• Theresa O'Keefe · Waltham, US
• Shixin Qin · Lexington, US
• John Babcook · Vancouver, CA

Key dates

• Filing date: Oct 22, 2010
• Grant date: Jul 22, 2014
• Expiry date: May 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.