Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors

US8785638B2 · kind B2 · utility

Assignee

• Katholieke Universiteit Leuven · BE

Inventors

• Dorothée Alice Marie-Eve Bardiot · Leuven, BE
• Patrick Chaltin · Zétrud-Lumay, BE
• Frauke Christ · Heverlee, BE
• Zeger Debyser · Heverlee, BE
• Marc De Maeyer · Heverlee, BE
• Arnaud Marchand · Leuven, BE
• Damien Marchand · Kessel-Lo, BE
• Arnout Voet · Zwevegem, BE

Key dates

• Filing date: May 17, 2010
• Grant date: Jul 22, 2014
• Expiry date: Sep 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a series of compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutic amount of such compounds, optionally combined with one or more other drugs having anti-viral activity.