Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8788034B2 · kind B2 · utility
66Cited by
239References
20Claims
0Family size
Assignee
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Key dates
| Filing date | May 9, 2012 |
| Grant date | Jul 22, 2014 |
| Priority date | — |
| Expiry date | May 9, 2032 |
Classification
- Technology area (CPC F)Mechanical Engineering; Lighting; Heating
- CPC primaryF04C2270/0421
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Described herein are methods and systems for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation. In particular, described herein are single supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >4 hours, greater than 12 hours, greater than 24 hours, greater than 48 hours) inhibition of pro-inflammatory cytokines and/or effects of chronic inflammation. These methods and devices are particularly of interest in treatment of inflammatory bowel disease (IBD).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.