Patent · US Active

Enhanced antimicrobial lytic activity of a chimeric Ply187 endolysin

US8790639B2 · kind B2 · utility

1Cited by

2References

17Claims

0Family size

Assignee

The United States of America, as represented by the Secretary of Agriculture · US

Inventors

David M. Donovan · Baltimore, US
Jinzhe Mao · Crofton, US

Key dates

Filing date	Mar 28, 2012
Grant date	Jul 29, 2014
Priority date	—
Expiry date	Mar 28, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall binding domain is a potent agent against Staphylococcus aureus in three functional assays.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.