Multimodular assembly useful for intracellular delivery
US8790664B2 · kind B2 · utility
71Cited by
4References
11Claims
0Family size
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Key dates
| Filing date | Sep 2, 2009 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | Apr 18, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.