Modified hyaluronic acid polymer compositions and related methods
US8790702B2 · kind B2 · utility
9Cited by
11References
35Claims
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Key dates
| Filing date | Jul 23, 2010 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | Dec 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2305/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.