Screening methods for compounds that modulate ARF-6 mediated endosomal redistribution
US8790887B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Dec 6, 2010 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | Dec 6, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to the field of disorders of the peripheral or central nervous system, in particular, Alzheimer's disease, and the prevention and/or treatment thereof. In particular, the invention relates to ARF6 and/or ARF6 effector proteins as new targets in Alzheimer's disease, and based thereon, screening methods for compounds that reduce amyloid beta peptide formation in mammalian cells by affecting ARF6-mediated endosomal sorting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.