Patent · US Active

Glycopegylated factor IX

US8791070B2 · kind B2 · utility

9Cited by

170References

20Claims

0Family size

Assignee

Novo Nordisk A/S · DK

Inventors

Shawn DeFrees · North Wales, US
Robert J. Bayer · San Diego, US
Caryn Bowe · Doylestown, US
Krishnasamy Paneerselvam · Poway, US

Key dates

Filing date	Oct 11, 2013
Grant date	Jul 29, 2014
Priority date	—
Expiry date	Oct 11, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21022
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Conjugates between Factor IX and PEG moieties. are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.