Methods for treating heart failure by inhibiting the mitochondrial sodium-calcium exchanger (mNCE)
US8791079B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Mar 11, 2010 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | May 18, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2300/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions for preventing or reducing the occurrence of conditions associated with heart failure, including, but not limited to, sudden cardiac death and contractile decompensation, by inhibiting the mNCE also are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.