Molecular tweezers for the treatment of amyloid-related diseases

US8791092B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• DEPARTMENT OF VETERANS AFFAIRS · US
• Massachusetts Institute of Technology · US
• UNIVERSITÄT DUISBURG-ESSEN · DE

Inventors

• Gal Bitan · Jerusalem, IL
• Akila Shanmugam · Allen, US
• Aleksey Lomakin · Swampscott, US
• Thomas Schrader · San Diego, US
• Frank Gerrit Klarner · Bochum, DE
• Peter Talbiersky · Bezirk Krems an der Donau (Stadt), AT
• Jolanta Polkowska · Essen, DE
• Frank Bastkowski · Braunschweig, DE
• Sharmistha Sinha · Ames, US
• Sally A. Frautschy · Santa Monica, US

Key dates

• Filing date: Mar 5, 2010
• Grant date: Jul 29, 2014
• Expiry date: May 3, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/4084
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.