Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

US8791101B2 · kind B2 · utility

Assignees

• ALBANY MOLECULAR RESEARCH, INC. · US
• Bristol-Myers Squibb Company · US

Inventors

• Bruce F. Molino · Slingerlands, US
• Shuang Liu · Schenectady, US
• Aruna Sambandam · Delmar, US
• Peter R. Guzzo · Niskayuna, US
• Min Hu · Schenectady, US
• Congxiang Zha · Schenectady, US
• Kassoum Nacro · Singapore, SG
• David D. Manning · Duanesburg, US
• Matthew Isherwood · Amherst, US
• Kristen N. Fleming · Clifton Park, US
• Wenge Cui · Clifton Park, US
• Richard E. Olson · Wilmington, US

Key dates

• Filing date: Nov 1, 2010
• Grant date: Jul 29, 2014
• Expiry date: Aug 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II):where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.