Compounds and methods for treatment of hypertension
US8791132B2 · kind B2 · utility
33Cited by
7References
62Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 17, 2012 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | May 31, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind to and antagonize adrenergic receptor α1B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.