Treatment and prophylaxis of amyloidosis

US8791243B2 · kind B2 · utility

Assignee

• Onclave Therapeutics Limited · IE

Inventors

• Dale B. Schenk · Burlingame, US
• Peter A. Seubert · South San Francisco, US
• Jonathan S. Wall · Knoxville, US
• Jose Saldanha · Ormskirk, GB

Key dates

• Filing date: Dec 29, 2008
• Grant date: Jul 29, 2014
• Expiry date: Oct 10, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/809
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.