Complex of amorphous tomoxiprole and cyclodextrin with fast dissolution rate and process for the preparation thereof
US8791269B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jun 14, 2012 |
| Grant date | Jul 29, 2014 |
| Priority date | — |
| Expiry date | Jun 14, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D235/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.