Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis

US8791300B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Wolfgang Hell · Aachen, DE
• Markus Kegel · Aachen, DE
• Helmut Buschmann · Walheim, DE
• Felix Spindler · Starrkirch-Wil, CH
• Detlef Heller · Rostock, DE
• Hans-Joachin Drexler · Erkrath, DE

Key dates

• Filing date: May 1, 2008
• Grant date: Jul 29, 2014
• Expiry date: Apr 9, 2029

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2531/827
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Compounds of the formula IIcan be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of R2 and R3 is not a hydrogen atom and the diphosphine ligand is chiral.