Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH
US8795658B2 · kind B2 · utility
1Cited by
6References
34Claims
0Family size
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Key dates
| Filing date | Sep 16, 2011 |
| Grant date | Aug 5, 2014 |
| Priority date | — |
| Expiry date | Dec 12, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other aspects, storage stabile aqueous formulations of immunoglobulins with histidine at a mildly acidic to neutral pH. The present invention also provides methods for stabilizing immunoglobulin compositions by formulating with histidine at a mildly acidic to neutral pH. Advantageously, the methods and formulations provided herein allow stabile aqueous compositions of immunoglobulins at mildly acidic to neutral pH useful for parenteral administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.