Immunoadsorption of anti-von Willebrand factor cleaving protease antibodies
US8795999B2 · kind B2 · utility
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2References
15Claims
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Key dates
| Filing date | Feb 18, 2009 |
| Grant date | Aug 5, 2014 |
| Priority date | — |
| Expiry date | Jan 1, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to adsorbents and methods for highly selective removal of anti-von Willebrand Factor-cleaving protease antibodies (“anti-vWF-cp-abs”) from human plasma using human von Willebrand Factor-cleaving protease (“hvWF-cp”) or fragments thereof as affinity ligands. The adsorbents can be used for treating disorders associated with the occurrence of anti-vWF-cp-abs in patients, such as thromboembolic diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.