Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-α modulators

US8796256B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Gilles Bignan · Bound Brook, US
• Wing S. Cheung · Plainsboro, US
• Micheal Gaul · Yardley, US
• Hui Huang · Blue Bell, US
• Xun Li · Huizhou, CN
• Raymond J. Patch · Yardley, US
• Sharmila Patel · Jamison, US
• Mark R. Player · Phoenixville, US
• Guozhang Xu · King of Prussia, US
• Bao-Ping Zhao · Plainsboro, US
• Jian Liu · Xi'an, CN

Key dates

• Filing date: May 24, 2011
• Grant date: Aug 5, 2014
• Expiry date: Dec 3, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of Formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin…