Method to produce an immunoglobulin preparation with improved yield

US8796430B2 · kind B2 · utility

Assignees

• Baxter International Inc. · US
• Baxter Healthcare SA · CH

Inventors

• Leopold Bruckschwaiger · Wien, AT
• Sonja Svatos · Ybbs an der Donau, AT
• Julia Nürnberger · Wien, AT
• Wolfgang Teschner · Wien, AT
• Harald Arno Butterweck · Wien, AT
• Hans-Peter Schwarz · Wien, AT
• Thomas Gundinger · Wien, AT
• Bernhard Koelbl · Achau, AT
• Reinhard Grausenburger · Wien, AT
• Azra Pljevljakovic · Wien, AT

Key dates

• Filing date: Apr 12, 2011
• Grant date: Aug 5, 2014
• Expiry date: Dec 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/34
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.