Rhodamine derivatives for photodynamic diagnosis and treatment
US8802082B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 29, 2013 |
| Grant date | Aug 12, 2014 |
| Priority date | — |
| Expiry date | Mar 29, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for reducing or preventing graft-versus-host disease associated with allogeneic stem cell transplantation are described. A method includes harvesting hematopoietic cells from a patient with an immunologic disorder and harvesting hematopoietic cells from a donor. The harvested hemaptopoietic cells from the patient and the donor are mixed ex vivo for a period of time sufficient to activate lymphocytes within the hematopoietic cells harvested from the donor such that an immune reaction occurs and an activated portion and an unactivated portion is produced. A rhodamine B derivative is then added to the mixture of cells and the mixture is irradiated at a suitable wavelength and intensity for the selective destruction and/or inactivation of the activated portion without substantially affecting the unactivated portion or causing systemic toxicity in said patient. The irradiated cells are then infused into the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.