Highly porous, fast-disintegrating solid dosage form and its way of manufacturing comprising the preparation of a powder and a freezedrying step
US8802145B2 · kind B2 · utility
3Cited by
5References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 27, 2005 |
| Grant date | Aug 12, 2014 |
| Priority date | — |
| Expiry date | Mar 26, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into cavities of blister packs or moulds, the remaining components dissolved in water dosed and added to the powder to form a moistened, plasticized mass, frozen to below −20° C., and the water sublimed in high vacuum. In this way solid dosage forms are obtained with a similar porous structure as usually result from freeze drying processes, but the process requires much less water, which means considerably less time and less energy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.