Patent · US Active

Modified pathogens for use as vaccines

US8802419B2 · kind B2 · utility

2Cited by

2References

20Claims

0Family size

Assignee

University of Massachusetts · US

Inventors

Egil Lien · Cambridge, US
Jon Goguen · Holden, US

Key dates

Filing date	Mar 2, 2006
Grant date	Aug 12, 2014
Priority date	—
Expiry date	Apr 16, 2027

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Described herein are microorganisms that are modified so that they have an increased ability to be recognized by the innate immune system of a eukaryote, relative to an unmodified microorganism. A microorganism may be a gram-negative bacterium that has been modified to produce high potency lipopolysaccharide, e.g., Yersinia pestis expressing LpxL. Such modified microorganisms may be used as vaccines for protection against an infection by the unmodified microorganism. They may also be used as delivery vehicles of one or more heterologous antigens, e.g., antigens from pathogens or those associated with a hyperproliferative eukaryotic cell.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.