Oligonucleotides for RNA interference and biological applications thereof
US8802640B2 · kind B2 · utility
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2References
11Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 1, 2006 |
| Grant date | Aug 12, 2014 |
| Priority date | — |
| Expiry date | Jul 17, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to compositions comprising double-stranded oligonucleotides of identical or different sequences and/or length, said oligonucleotides having sequences 3′N1N2 . . . Ni-1Ni . . . Nj5′ wherein—3′Ni . . . Nj5′ is half of a double-stranded 19-28mer oligonucleotide of sequence complementary to a target nucleic acid sequence present in a living cell, and—3′N1 . . . Ni-15′ is a 3-50mer overhang of sequence allowing oligomerization of said double-stranded oligonucleotide. Compositions of transfection comprising said oligonucleotide compositions and there used for therapeutical application.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.