Bicyclic aryl sphingosine 1-phosphate analogs

US8802659B2 · kind B2 · utility

Assignee

• BIOGEN IDEC MA INC. · US

Inventors

• Jermaine Thomas · Chelsea, US
• Xiaogao Liu · Dover, US
• Edward Yin-Shiang Lin · Ashland, US
• Guo Zhu Zheng · Lexington, US
• Bin Ma · Arlington, US
• Richard D. Caldwell · Melrose, US
• Kevin M. Guckian · Northborough, US
• Gnanasambandam Kumaravel · Westford, US
• Arthur G. Taveras · Rockaway, US

Key dates

• Filing date: Aug 5, 2010
• Grant date: Aug 12, 2014
• Expiry date: Sep 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.