Dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof

US8802669B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Song Li · Beijing, CN
• Xiaoqian Xu · Beijing, CN
• Guoming Zhao · Beijing, CN
• Lili Wang · Beijing, CN
• Hua Guan · San Diego, US
• Junhai Xiao · Beijing, CN
• Wu Zhong · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Yunde Xie · Beijing, CN
• Xingzhou Li · Beijing, CN
• Xiaokui Wang · Beijing, CN
• Xinbo Zhou · Beijing, CN
• Hongying Liu · Beijing, CN

Key dates

• Filing date: May 27, 2010
• Grant date: Aug 12, 2014
• Expiry date: Mar 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.