Patent · US Active

Pharmaceutical compositions with attenuated release of phenolic opioids

US8802681B2 · kind B2 · utility

21Cited by

9References

54Claims

0Family size

Assignee

Signature Therapeutics, Inc. · US

Inventors

Thomas E. Jenkins · Louisville, US
Julie D. Seroogy · Redwood City, US
Jonathan W. Wray · San Francisco, US

Key dates

Filing date	Oct 16, 2009
Grant date	Aug 12, 2014
Priority date	—
Expiry date	May 6, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2603/80
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.