High pressure refolding of monoclonal antibody aggregates
US8802828B2 · kind B2 · utility
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Key dates
| Filing date | Feb 27, 2012 |
| Grant date | Aug 12, 2014 |
| Priority date | — |
| Expiry date | Feb 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.