Process for preparing vilazodone hydrochloride
US8802851B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Apr 2, 2013 |
| Grant date | Aug 12, 2014 |
| Priority date | — |
| Expiry date | Apr 2, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates, in a first aspect, to a process preparing vilazodone hydrochloride that comprises the reaction of 3-(4-chloro-1-hydroxy-butyl)-1H-indol-5-carbonitrile with 5-piperazin-1-yl-benzofuran-2-carboxylate methyl hydrochloride with the formation of a 1,4-piperazine, with subsequent dehydration, hydrogenation and treatment with ammonia, to obtain vilazodone in free base form that is then converted into the hydrochloride thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.