Pyridinylimidazolone derivatives for the inhibition of PI3 kinases

US8802866B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Ulrich Emde · Darmstadt, DE
• Hans-Peter Buchstaller · Griesheim, DE
• Markus Klein · Weiterstadt, DE
• Christina Esdar · Darmstadt, DE
• Joerg Bomke · Heidelberg, DE

Key dates

• Filing date: Sep 6, 2010
• Grant date: Aug 12, 2014
• Expiry date: May 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I), in which X1, X2, L, Y, R2, R3, R4, R5, R6, R7, R8, R9, R10 have the meanings indicated in claim 1, are PI3K inhibitors and can be employed, inter alia, for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumors.