Patent · US Active

Chemically and biologically modified medical devices

US8808365B2 · kind B2 · utility

1Cited by

9References

26Claims

0Family size

Inventors

Martin Kean Chong Ng · Forbes, AU
Anna Waterhouse · Brookline, US
Anthony Steven Weiss · Sydney, AU
Steven Garry Wise · Parramatta, AU

Key dates

Filing date	Jan 6, 2010
Grant date	Aug 19, 2014
Priority date	—
Expiry date	Oct 28, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61L2400/18
WIPO fieldMedical technology
WIPO sectorInstruments

Abstract

Biocompatible materials for use in vascular applications or for implantation have been engineered, combining human recombinant tropoelastin with other synthetic or natural biomaterials to form protoelastin. The materials can be in the form of elastin films on metal or polymer substrates, laminates of alternating polymer and elastin, blends of polymer and elastin, or elastin crosslinked with or tethered to polymer or metal. These are mechanically stable, elastic, strong and biocompatible (i.e., not thrombogenic and promoting adhesion of cells, especially human endothelial cells), not eliciting a foreign body response. Plasma polymerization of substrate is shown to enhance biocompatibility, especially when used to bind elastin or other protein to the substrate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.