Method of treatment using organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1α
US8808685B2 · kind B2 · utility
2Cited by
14References
9Claims
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Key dates
| Filing date | Aug 1, 2011 |
| Grant date | Aug 19, 2014 |
| Priority date | — |
| Expiry date | May 6, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/99
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.