Method of controlled drug release from a liposome carrier

US8808733B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Daniel Fologea · Boise, US
• Greg Salamo · Fayetteville, US
• Ralph Henry · Fayetteville, US
• Michael J. Borrelli · Little Rock, US
• Peter M. Corry · Little Rock, US

Key dates

• Filing date: Mar 31, 2010
• Grant date: Aug 19, 2014
• Expiry date: May 15, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods and compositions for the controlled release of a drug or agent from a liposome using light or radiation. Also disclosed are compositions comprising liposomes having a lipid layer, wherein the liposomes contain an agent, an enzyme capable of releasing the agent from the liposome, and an enzyme activator sequestered by a molecular cage. In another aspect, methods of delivering an agent to a target in a subject are disclosed.