Methods related to liver enzyme induction as a predisposition for liver toxicity and diseases or disorders associated therewith

US8808979B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Bennard van Ravenzwaay · Altrip, DE
• Werner Mellert · Haßloch, DE
• Georgia Coelho Palermo Cunha · São Paulo, BR
• Eric Fabian · Ludwigshafen, DE
• Volker Strauss · Bad Dürkheim, DE
• Hennicke Kamp · Bischheim, DE
• Tilmann B. Walk · Kleinmachnow, DE
• Ralf Looser · Berlin, DE
• Michael Manfred Herold · Berlin, DE
• Jan C. Wiemer · Berlin, DE
• Alexandre Prokoudine · Berlin, DE
• Edgar Leibold · Bischofswerda, DE

Key dates

• Filing date: May 25, 2009
• Grant date: Aug 19, 2014
• Expiry date: May 25, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/60
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fa…