Patent · US Active

Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor

US8809024B2 · kind B2 · utility

0Cited by

11References

14Claims

0Family size

Assignee

ASTRAZENECA AB · SE

Inventors

Michael Politino · Syracuse, US
Matthew M. Cadin · Auburn, US
Jason G. Chen · Manlius, US

Key dates

Filing date	Jan 4, 2013
Grant date	Aug 19, 2014
Priority date	—
Expiry date	Jan 4, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y102/02001
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structureprepared by subjecting an acid of the structureto reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2with di-tert-butyl dicarbonate to form the BOC-protected amine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.