Methods and compositions to generate and control the effector profile of T cells by simultaneous loading and activation of selected subsets of antigen presenting cells
US8809290B2 · kind B2 · utility
2Cited by
35References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 1, 2011 |
| Grant date | Aug 19, 2014 |
| Priority date | — |
| Expiry date | Apr 14, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-γ, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.