Sulfonamides as TRPM8 modulators

US8809327B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Shawn Branum · Raritan, US
• Raymond W. Colburn · Spring House, US
• Scott L. Dax · Landenberg, US
• Christopher Flores · Lansdale, US
• Michele C. Jetter · Norristown, US
• Yi Liu · San Diego, US
• Donald Ludovici · Quakertown, US
• Mark J. Macielag · Spring House, US
• Jay M. Matthews · Lansdale, US
• James J. McNally · Souderton, US
• Laura M. Reaney · Spring House, US
• Ronald K. Russell · Titusville, US
• Ning Qin · Blue Bell, US
• Christopher A. Teleha · Fort Washington, US
• Kenneth M. Wells · Somerville, US
• Scott C. Youells · Spring House, US
• Mark A. Youngman · Warminster, US

Key dates

• Filing date: Feb 28, 2012
• Grant date: Aug 19, 2014
• Expiry date: Feb 28, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.