Compounds and methods for inhibiting phosphate transport

US8809339B2 · kind B2 · utility

Assignee

• ARDELYX, INC. · US

Inventors

• Jason G. Lewis · Castro Valley, US
• Jeffrey W. Jacobs · Fremont, US
• Nicholas Reich · Berkeley, US
• Michael R. Leadbetter · Fremont, US
• Noah Bell · Fremont, US
• Han-Ting Chang · Livermore, US
• Tao Chen · 安丰镇, CN
• Marc Navre · Belmont, US
• Dominique Charmot · Campbell, US
• Christopher Carreras · Belmont, US
• Eric Labonte · Redwood City, US

Key dates

• Filing date: Jan 4, 2013
• Grant date: Aug 19, 2014
• Expiry date: Jan 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.