Inhibitors of NEDD8-activating enzyme
US8809356B2 · kind B2 · utility
10Cited by
4References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2012 |
| Grant date | Aug 19, 2014 |
| Priority date | — |
| Expiry date | Sep 17, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.