Oxazolone and pyrrolidinone-substituted biphenyls as P2X3 and P2X2/3 antagonists

US8809402B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Li Chen · Sha Tin, CN
• Michael Patrick Dillon · Mill Valley, US
• Lichun Feng · Shanghai, CN
• Minmin Yang · Nanjing, CN

Key dates

• Filing date: Dec 8, 2011
• Grant date: Aug 19, 2014
• Expiry date: Dec 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.