Synthesis of cyclopentaquinazolines

US8809526B2 · kind B2 · utility

Assignee

• Onyx Pharmaceuticals, Inc. · US

Inventors

• James Alan Kerschen · Somerville, US
• Alexander James Bridges · Saline, US
• Sean Dalziel · Burlingame, US
• Olivier Dapremont · Cameron Park, US
• Hyunjung Kim · Collegeville, US
• Andrew S. Thompson · Mountainside, US
• James Robert Zeller · Holland, US

Key dates

• Filing date: Jul 15, 2011
• Grant date: Aug 19, 2014
• Expiry date: Jul 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/70
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).