Methods for detecting gene dysregulation by intragenic differential expression
US8815516B2 · kind B2 · utility
10Cited by
8References
20Claims
0Family size
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Key dates
| Filing date | Mar 22, 2013 |
| Grant date | Aug 26, 2014 |
| Priority date | — |
| Expiry date | Mar 22, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5′ portion of a target gene relative to the 3′ region of the target gene.
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