Methods and reagents for identifying/isolating T regulatory (Treg) cells and for treating individuals
US8815526B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 31, 2006 |
| Grant date | Aug 26, 2014 |
| Priority date | — |
| Expiry date | Feb 25, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/205
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an antibody and may be used to identify Treg cells. A method comprises providing a blood sample from a subject and determining the amount of Treg cells in that sample. A composition containing Treg cells may be administered to an individual to suppress effector T cell activity in the individual. A composition containing an affinity ligand capable of binding to a GARP domain may be administered to an individual to suppress Treg cell activity and increase effector T cell activity in the individual. A kit for detecting Treg cells may include an affinity ligand reactive with mammalian GARP protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.