Mammalian cell expressing Volvox carteri light-activated ion channel protein (VChR1)

US8815582B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Karl Deisseroth · Stanford, US
• Feng Zhang · Cambridge, US
• Viviana Gradinaru · Irvine, US

Key dates

• Filing date: Dec 18, 2012
• Grant date: Aug 26, 2014
• Expiry date: Jan 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14143
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule.